Education

- Ph.D. 2015, Biomedical Science, CHA University

- M.S. 2012, Biomedical Science, CHA University

- B.S. 2010, Marine Bioscience and Technology, Gangneung National University

Experiences

 - Postdoctoral Associate. Feinberg Medical school, Northwestern University, Chicago, USA.

Intellectual properties

 -  Microenvironmental changes induced by placenta-derived mesenchymal stem cells restore ovarian function in ovariectomized rats via activation of the PI3K-FOXO3 pathway. 1020170040442.

 -  Pharmaceutical composition for preventing or treating ovary dysfunction or menopausal syndrome comprising placenta-derived stem cells. 1020170022369.

 -  Pharmaceutical composition for preventing or treating cholestatic liver injury or hyperlipidemia comprising placenta-derived mesenchymal stem cells). 1020200052140.

Journal Articles

-Application of Fibronectin-Coated Microparticles for Isolation of Human iPSC-Derived MSCs. Tissue Eng Regen Med. 2026.

-4-Hexylresorcinol Attenuates Ethanol-Induced Hepatic and Pancreatic Injury by Modulating Metabolic Dysfunction and Endoplasmic Reticulum Stress. Biomedicines. 2026.

-Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw. Oral Dis. 2026.

-Increased BMP/SMAD Signaling by PD-MSCs Promotes Bone Formation in an Ovariectomized Mouse Model of Osteoporosis. Int J Mol Sci. 2025.

-Functional Effects of Sericin on Bone Health and D-Serine Regulation in Estrogen-Deficient Rats. Appl Sci. 2025

-The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments. Mol Oncol. 2025.

-Sericin’s Potential in Osteoporosis Management: The Roles of L-Serine and D-Serine in Bone Metabolism Regulation. Nutrients. 2025.

-The Application of L-Serine-Incorporated Gelatin Sponge into the Calvarial Defect of the Ovariectomized Rats. Tissue Eng Regen Med. 2024.

-miRNA-199b-5p suppresses of oral squamous cell carcinoma by targeting apical-basolateral polarity via Scribble/Lgl. Molecular Therapy Nucleic Acids. 2024.

-The e-x-p-r-e-s-s-i-o-n of PTTG1 as a biomarker and impact on invasion and growth of oral squamous cell carcinoma. The Korean J Oral and Maxillofacial Pathol. 2023.

-Hypoxia disrupt tight junctions and promote metastasis of oral squmous cell carcinoma via loss of par3. Cancer Cell International. 2023.

-microRNA-126 promotes the proliferation and migration of oral squamous cell carcinoma cells via HIF-1alpha e-x-p-r-e-s-s-i-o-n. The Korean J Oral and Maxillofacial Pathol. 2023.

-microRNA-18a regulates the metastatic properties of oral squamous cell carcinoma cells via HIF-1 e-x-p-r-e-s-s-i-o-n. BMC Oral Health. 2022.

-Increased phosphatase of regenerating liver-1 by placental stem cells promotes hepatic regeneration in a bile- duct ligated rat model. Cells. 2021.

-Alteration of pituitary tumor transforming gene 1 by microRNA-186 and 655 regulates invasion ability of human oral squamous cell carcinoma. Int J Mol Sci. 2021.

-Efficacy of gene modification in placenta-derived mesenchymal stem cells based on nonviral electroporation. Int J Stem Cells. 2021.

-Microenvironmental changes induced by placenta-derived mesenchymal stem cells restore ovarian function in ovariectomized rats via activation of the PI3K-FOXO3 pathway. Stem Cell Res Ther. 2020.

-Enhanced PRL-1 e-x-p-r-e-s-s-i-o-n in placenta-derived mesenchymal stem cells accelerates hepatic function via mitochondrial dynamics in a cirrhotic rat model. Stem Cell Res Ther. 2020.

-Exosomes from placenta-derived mesenchymal stem cells are involved in liver regeneration in hepatic failure induced by bile duct ligation. Stem Cell Int. 2020

-Placenta-derivedmesenchymalstemcellsrestorethe ovary function in an ovariectomized rat model via an antioxidant effect. Antioxidants (Basel). 2020.

-Alterations of Il-6/STAT3 signal by Korean mistletoe lectin regulate self-renewal activity of placenta-derived mesenchymal stem cells. Nutrients. 2019.

-Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex. J Cell Biol. 2019 Jul 218(7):2277-2293.

-Spatial and temporal organization of cadherin in punctate adherens junctions. Proc Natl Acad Sci U S A. 2018 May 115(19):E4406-4415.

-Immunomodulatory Effects of Placenta-derived Mesenchymal Stem Cells on T Cells by Regulation of FoxP3 e-x-p-r-e-s-s-i-o-n. Int J Stem Cells. 2018 Nov 30;11(2):196-204.

-3D-cultured human placenta-derived mesenchymal stem cell spheroids enhance ovary function by inducing folliculogenesis. Sci Rep. 2018 Oct 17;8(1):15313.

-Spatial and temporal organization of cadherin in punctate adherens junctions. Proc Natl Acad Sci U S A. 2018 May 8;115(19)

-Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation. Stem Cells Int. 2017;2017:5180579.

-Decreased C-reactive protein induces abnormal vascular structure in a rat model of liver dysfunction induced by bile duct ligation. Clin Mol Hepatol. 2016 Sep;22(3):372-381

-Hypoxia Inducible Factor-1 Regulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrin 4. Stem Cells Int. 2016;2016:7932185.

-Microenvironmental Interaction Between Hypoxia and Endothelial Cells Controls the Migration Ability of Placenta-Derived Mesenchymal Stem Cells via 4 Integrin and Rho Signaling. J Cell Biochem. 2016 May;117(5):1145-57.

-Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma. Cancer Genet. 2015 May; 261-70.

-Epigenetic Alteration of IL-6/STAT3 signaling by placental stem cells promote hepatic regeneration in a rat model with CCl4-induced liver injury. Int J Stem Cells. 2015 May; 79-89.

-Effect of mesenchymal stem cells and extracts derived from the placenta on trophoblast invasion and immune responses. Stem Cells Dev. 2014. Jan; 13245.

-Korean mistletoe lectin promotes proliferation and invasion of trophoblast cells.through regulation of Akt signaling. Reprod Toxicol. 2013 Aug; 39:33-9.

-Effect of Immortalization-Upregulated Protein-2(IMUP-2) on Cell Death of Trophoblast. Dev. Reprod. 2013 June;17: 99-109.

-Human Placenta-Derived Mesenchymal Stem Cells Promote Hepatic Regeneration in Ccl(4)-Injured Rat Liver Model Via Increased Autophagic Mechanism. Stem Cells. 2013 Aug:31(8):1584-96

-Altered e-x-p-r-e-s-s-i-o-n of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion. Clin Exp Reprod Med. 2013 Mar;40(1):12-22.

-Korean mistletoe lectin regulates self-renewal of placenta-derived mesenchymal stem cells via autophagic mechanisms. Cell Prolif. 2012 Oct;45(5):420-9.

-Effects of hypoxia inducible factors-1 on autophagy and invasion of trophoblasts. Clin Exp Reprod Med. 2012 Jun;39(2):73-80.

-Dynamic alterations in integrin 4 e-x-p-r-e-s-s-i-o-n by hypoxia are involved in trophoblast invasion during early implantation. J Cell Biochem. 2012 Feb;113(2):685-94.

-Effect of hypoxia-induced XIAP e-x-p-r-e-s-s-i-o-n on apoptosis of trophoblast cell in placenta. Clin Exp Reprod Med. 2010.

-Isolation and characterization of trophoblast stem cells-like cells derived from human term placenta. Dev. Reprod. 2010. 155-162.